Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1997-03-06
1998-11-24
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, 556489, 556482, A61K 3159
Patent
active
058407189
ABSTRACT:
The invention relates to a compound of the formula ##STR1## wherein R is hydroxy and R.sup.1 is H.sub.2 or .dbd.CH.sub.2 or R is hydrogen or fluoro and R.sup.1 is .dbd.CH.sub.2 and (b) an inert carrier.
Compounds of formula I are useful as agents for the treatment of hyperproliferative skin diseases, such as psoriasis, neoplastic diseases, such as leukemia, and sebaceous gland diseases, such as acne and sebhorreic dermatitis.
REFERENCES:
patent: 5087619 (1992-02-01), Baggiolini
patent: 5384314 (1995-01-01), Doran et al.
patent: 5612328 (1997-03-01), Baggiolini et al.
A.S. Craig, A.W. Norman, W.H. Okamura, J. Org. Chem. 57, pp. 4374-4380 (1992).
Hennessy Bernard Michael
Iacobelli Jerome Anthony
Uskokovic Milan Radoje
Hoffmann-La Roche Inc.
Johnston George W.
Kirk, Jr. Joseph P.
Reamer James H.
Tramaloni Dennis P.
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