22-Cyano-24-norcholanes

Details 22-Cyano-24-norcholanes 22-Cyano-24-norcholanes

1974-05-13

1976-03-16

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424182, 26023955R, 26023957, C07J 1900

Patent

active

039445410

ABSTRACT:
There are disclosed herein the 3.beta., 14-dihydroxy-,3.beta.,5,14-trihydroxy-, 3.beta.,12.beta.,14-trihydroxy- and 3.beta.,14,16.beta.-trihydroxy-21,23-epoxy-23-methoxy-24-nor-5.beta.,1 4.beta.-chola-20,22-diene-22-carbonitriles, as well as their corresponding 3-acetates, 3-propionates and 3-butyrates and their 3-digitosides and 3.beta.-cyamarosyl-glucosides as encountered in naturally-occuring starting materials. The compounds possess useful cardiotonic activity. Also included are the corresponding 22-cyano-5.beta.-card-20(22)-enolides, useful as intermediates in the preparation of the compounds of this invention and also as cardiotonic agents.

REFERENCES:
patent: 3852265 (1974-12-01), Hartenstein et al.

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