Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-08-22
2006-08-22
Fredman, Jeffrey (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C435S455000, C536S023100, C536S023500, C530S350000
Reexamination Certificate
active
07094565
ABSTRACT:
The present invention relates to newly identified human ADHs belonging to the superfamily of mammalian alcohol dehydrogenases. The invention also relates to polynucleotides encoding the ADHs. The invention further relates to methods using the ADH polypeptides and polynucleotides as a target for diagnosis and treatment in ADH-mediated or -related disorders. The invention further relates to drug-screening methods using the ADH polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADH polypeptides and polynucleotides. The invention further relates to procedures for producing the ADH polypeptides and polynucleotides.
REFERENCES:
Duester et al., Families of retinoid dehydrogenases regulating vitamin A function production of visual pigment and retinoic acid, 2000, Eur. J. Biochem, vol. 267, pp. 4315-4324.
Rosenberg et al., Gene therapist, Heal thyself, 2000, SCIENCE, vol. 287, p. 1751.
Wood, Phenotype Assessment: Are you Missing Something?, 2000, Comparative Medicine, vol. 50, pp. 12-15.
AA622988/c, NCI-CGAP http://www.ncbi.nlm.nih.gov
cicgap, Oct. 1997.
Krozowski, Z., “The Short-chain Alcohol Dehydrogenase Superfamily: Variations on a Common Theme,”J. Steroid Biochem. Molec. Biol.,1994, pp. 125-130, vol. 51.
Yoshida, et al., “Genetics of Human Alcohol-Metabolizing Enzymes,”Progress in Nucleic Acid Research and Molecular Biology,1991, pp. 255-287, vol. 40.
EMBL Database for Accession No. AC003042, Nov. 5, 1997 (XP002173560).
EMBL Database for Accession No. Q9XYN2, Nov. 1, 1992 (XP002173561).
EMBL Database for Accession No. 034187, Jan. 1, 1998 (XP002173562).
EMBL Database for Accession No. 025124, Jan. 1, 1998 (XP002173563).
Blast searches of clone 21615 against the following databases: NRN
uc; NRP/protxnu; patent 2/gsprot; Patent DbPreviewNuc; patent 2/gsnuc; DBEST/dbEST.
Blast searches of clone 21676 against the following databases: db/NRN
uc; DBEST/dbEST; Patent 2/Patent DbPreviewNuc; and Patent 2/gsnuc.
Blast searches of clone 21612 against the following datagases: DBEST/dbEST; db/NRN
uc; PatentDbPreviewNuc; Patent 2/gsnuc; Patent 2/gsprot; NRP/protot.
Clustal W (V 1.74) pairwise sequence alignment of clone 21612.
Blast searches for clone 21620 against the folowing databases: DBEST/dbEST; NRN
uc; Patent 2/Patent DbPreviewNuc; Patent 2/gsnuc; Patent 2/gsprot; NRP/protot; and NRP/protxnu.
Clustal W (V 1.74) pairwise alignment of clone 21620.
Blast searches of clone 33756 against the following databases: DBEST/dbEST; NRN
uc; Patent 2/Patent DbPreviewNuc; Patent 2/gsnuc; Patent 2/gsprot; NRP/protot; NRP/protxnu.
Clustal W (V 1.74) pairwise alignment of clone 33756.
Fredman Jeffrey
Kaushal Sumesh
Millennium Pharmaceuticals Inc.
Millennium Pharmaceuticals Inc.
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