21-substituted progesterone derivatives as new...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S182000, C514S841000, C552S556000, C552S595000, C552S598000, C552S602000, C552S608000

Reexamination Certificate

active

06861415

ABSTRACT:
A compound having the general formula:in which: R1is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3and —CHOHCH3; R2is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R3is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR5, wherein R5is a member selected from the group consisting of hydrogen and alkyl.In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception.

REFERENCES:
patent: 4386085 (1983-05-01), Teutsch et al.
patent: 4477445 (1984-10-01), Philibert et al.
patent: 4634695 (1987-01-01), Torelli et al.
patent: 4808710 (1989-02-01), de Jongh et al.
patent: 4912097 (1990-03-01), Teutsch et al.
patent: 4921845 (1990-05-01), de Jongh et al.
patent: 4943566 (1990-07-01), Nedelec et al.
patent: 4954490 (1990-09-01), Cook et al.
patent: 5064822 (1991-11-01), Philibert et al.
patent: 5073548 (1991-12-01), Cook et al.
patent: 5089488 (1992-02-01), Ottow et al.
patent: 5166199 (1992-11-01), Kasch et al.
patent: 5173483 (1992-12-01), Grandadam
patent: 5272140 (1993-12-01), Loozen
patent: 5364847 (1994-11-01), Labrie et al.
patent: 5426102 (1995-06-01), Schwede et al.
patent: 5446036 (1995-08-01), Scholz et al.
patent: 5741787 (1998-04-01), Peeters
patent: 1307784 (1992-09-01), None
patent: 057 115 (1982-08-01), None
patent: 129 499 (1984-06-01), None
patent: 136 586 (1984-09-01), None
patent: WO 8912448 (1989-12-01), None
Cook, et al.,Life Sciences, 52(2):155-162 (1993).
Cook, et al.,J. Steroid Biochem., vol. 25, Abstract 365(1986).
Heikinheimo, et al.,J. Steroid Biochem., 26(2):279-284 (1987).
Horwitz,Endocrinology, 116(6):2236-2245 (1985).
Kloosterboer, et al.,J. steroid Biochem., 31(4B):567-571 (1988).
Livingston, et al.,J. Am. Chem. Soc., 112:6449-6450 (1990).
Livingston,Adv. Med. Chem., 1:137-174 (1992).
Nieman, et al.,J. Clin. Endocrin. Metab., 61(3):536-540 (1985).
Spitznagle, et al.,Steroids, 30(4):435-438 (1977).
Teutsch, et al.,Human Reproduction, 9(1):12-31 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

21-substituted progesterone derivatives as new... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 21-substituted progesterone derivatives as new..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 21-substituted progesterone derivatives as new... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3453768

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.