(20S)-1α-hydroxy-2α-methyl and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C552S653000

Reexamination Certificate

active

06844330

ABSTRACT:
This invention discloses (20S)-1α-hydroxy-2α-methyl-19-nor-vitamin D3and (20S)-1α-hydroxy-2β-methyl-19-nor-vitamin D3and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have very significant calcemic activity and therefore may be used to treat immune disorders in humans as well as metabolic bone diseases such as osteoporosis.

REFERENCES:
patent: 5391755 (1995-02-01), DeLuca et al.
patent: 5581006 (1996-12-01), DeLuca et al.
patent: 5945410 (1999-08-01), DeLuca et al.
patent: 6127559 (2000-10-01), DeLuca et al.
patent: 6306844 (2001-10-01), DeLuca et al.
patent: 6667298 (2003-12-01), DeLuca et al.
patent: 6683219 (2004-01-01), DeLuca et al.
Sicinski et al, “New 1 Alpha-25-Dihydroxy-19-Norvitamin D3 Compounds of High Biological Activity: Synthesis and Biological Evaluation of 2-Hydroxymethyl, 2-Methyl, and 2-Methylene Analogues,” Journal of Medicinal Chemistry, American Chemical Society, Oct. 22, 1998, pp. 4662-4674, vol. 41, XP002105465.
Bouillon et al, “Structure-Function Relationships in the Vitamin D Endocrine System,” Endocrine Reviews, Apr. 1995, pp. 200-257, vol. 16, No. 2, XP002247361.
Castedo et al, Palladium-Catalyzed Synthesis of Dienynes Related to Vitamin D from Enol Triflates, Tetrahedron Letters, 1986, pp. 1523-1526, vol. 27, No. 13, XP009013726.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

(20S)-1α-hydroxy-2α-methyl and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (20S)-1α-hydroxy-2α-methyl and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (20S)-1α-hydroxy-2α-methyl and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3423306

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.