20-substituted pregnene derivatives and their use as androgen sy

Details 20-substituted pregnene derivatives and their use as androgen sy 20-substituted pregnene derivatives and their use as androgen sy

1992-01-29

1993-11-23

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552601, 552602, A61K 3156

Patent

active

052644278

ABSTRACT:
Novel 20-substituted-pregnene derivatives, compositions containing such derivatives and methods for their use and manufacture are disclosed. The 20-substituted-pregnene derivatives inhibit the androgen biosynthesis enzymes 17(alpha)-hydroxylase/C.sub.17,20 -lyase and 5(alpha)-reducatase and are therefore useful for reducing or inhibiting production of androgens where they have an adverse role in a disease or physiological condition in vertebrate species.

REFERENCES:
Krause, et al. Steroids, 31(6) pp. 823-839 (1978).
Li et al., J. Steroid Biochem. Molec. Biol., 42: 313-320 (1992).

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