20-position modified pharmaceutically active vitamin D series co

Details 20-position modified pharmaceutically active vitamin D series co 20-position modified pharmaceutically active vitamin D series co

1993-06-24

1996-12-17

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07C40100

Patent

active

055853684

ABSTRACT:
The invention relates to vitamin D derivatives, modified in 20-position, of general formula I ##STR1## in which X, Y, Z, R.sub.1, R.sub.2 as well as R.sub.3 have the meaning indicated in the description, process for their production and their use as agents for treatment of hyperproliferative diseases of the skin.

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Sarandeses, et al, Tetrahedron, vol. 49(3), 1993, pp. 731-738.
Kubodera et al., "Synthetic Studies of Vitamin D Analogues. X. Synthesis and Biological Activities of 1.alpha., 25-Dihydroxy-21-norvitamin D.sub.3 ", Chemical & Pharmaceutical Bulletin, vol. 40, No. 3 (Mar. 1992), pp. 648-651.
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