20-O-Acylmaytansinoids

Details 20-O-Acylmaytansinoids 20-O-Acylmaytansinoids

1980-01-15

1981-10-13

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424854, C07D49818

Patent

active

042947570

ABSTRACT:
Novel 20-demethoxy-20-acyloxymaytansinoids representable by the formula: ##STR1## [wherein X is chlorine or hydrogen; R.sub.1 is hydrogen or acyl group; R.sub.2 is acyl group] are produced from 20-demethoxy-20-hydroxymaytansinoids by means of acylation.
The compounds are useful as antifungal, antiprotozoal or antitumor agent.

REFERENCES:
patent: 3631176 (1971-12-01), Klopping
patent: 3770775 (1973-11-01), Paolo et al.
patent: 3829437 (1974-08-01), Zumach et al.
patent: 3896111 (1975-07-01), Kupchan et al.
patent: 4137230 (1979-01-01), Hashimoto et al.
patent: 4190580 (1980-02-01), Hashimoto et al.
CA. 1972-1976 Chem. Substance Index, 13927 CS, MBR 5601.
Kupchan et al., J.A.C.S., vol. 97, No. 18, 1975.
Kupchan et al., Jour. Medicinal Chem., 1978, vol. 21, No. 1.

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