20-hydroxyeicosatetraenoic acid production inhibitors

Details 20-hydroxyeicosatetraenoic acid production inhibitors 20-hydroxyeicosatetraenoic acid production inhibitors

2007-05-08

2007-05-08

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S183000, C514S217120, C514S227500, C514S235500, C514S235800, C514S238200, C514S253010, C514S253130, C514S254010, C514S255010, C514S255030, C514S278000, C514S311000, C514S315000, C514S318000, C514S326000, C514S327000, C514S330000, C514S331000, C514S357000, C514S428000, C540S481000, C540S483000, C540S609000, C544S059000, C544S121000, C544S124000, C544S166000, C544S360000, C544S372000, C544S391000, C544S392000, C546S019000, C546S164000, C546S193000, C546S216000, C546S227000, C546S231000, C546S325000, C546S

Reexamination Certificate

active

10475869

ABSTRACT:
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof[wherein R1represents a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazepin-1-yl group, a perhydroazocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrrolin-1-yl group, etc.; X represents a nitrogen atom or a group represented by CR5; and R2to R5are the same or different and each represents a hydrogen atom, a C1-4alkyl group, a C1-4alkoxy group, a trifluoromethyl group or a halogen atom.]There is provided a drug which inhibits an enzyme producing 20-HETE participating in a contracting or dilating action for microvessels and an inducing action for cell proliferation in main organs such as kidney and cerebrovascular vessels.

REFERENCES:
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patent: 6864254 (2005-03-01), Sato et al.
patent: 2004/0110830 (2004-06-01), Sato et al.
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Alonso-Galicia, M. et al. “Inhibition of 20-HETE Production Contributes to the Vascular Responses to Nitric Oxide”, Hypertension, vol. 29, No. 1, Jan. 1997, pp. 320-325.

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