20-HETE synthase inhibitor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S238800, C514S248000, C514S256000, C514S258100, C514S262100, C514S310000, C514S311000, C514S312000, C514S328000, C514S331000, C514S346000, C514S357000, C514S359000, C514S364000, C514S366000, C514S367000, C514S370000, C514S380000, C514S406000, C514S411000, C514S416000, C514S424000, C514S427000, C514S428000, C514S430000, C514S438000, C514S443000, C514S449000, C514S452000, C514S456000, C514S459000, C514S467000, C514S471000, C514S568000, C514S633000, C514S637000

Reexamination Certificate

active

07078400

ABSTRACT:
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present invention are useful as therapeutic agents for kidney diseases, cerebrovascular diseases, or circulatory diseases.In addition, the present invention also provides novel hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof.

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Zinner et al,Chem.-Ztg., 98(3):159 (1974), Abstract.
Hussein et al,Bull. Coll. Sci. Univ. Baghdad, 14:79-87 (1973), Abstract.
Hayakawa et al,J. Pesticide Sci., 17(1):17-25 (1992).
Alonso-Galicia et al,Hypertension, 29(1):320-325 (1997).

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