20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin

Details 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin 20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin

1983-08-22

1985-07-09

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 76, 514 30, 536 168, C07H 1708, C12P 1962, A61K 3171

Patent

active

045283699

ABSTRACT:
20-Dihydro-20-deoxy-23-de(mycinosyloxy)tylosin (20-deoxo-DMOT), specified 2'-acyl ester derivatives, and their acid addition salts are useful intermediates and antibacterial agents. Methods of preparing 20-deoxo-DMOT and 5-O-mycaminosyltylactone by fermentation of Streptomyces fradiae ATCC 31733 are included.

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Hackh's, "Chemical Dictionary", 4th Ed., p. 312.
H. Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and its Structure-Activity Relationship", Chem. Pharm. Bull., 30, (1), 97-110, (1982).
A. Nagel et al., "Selective Cleavage of the Mycinose Sugar from the Macrolide Antibiotic Tylosin: A Unique Glycosidic Scission", J. Org. Chem., 44, (12), 2050-2052, (1979).
A. Kinumaki et al., "Macrolide Antibiotics M-4365 Produced by Micromonospora II. Chemical Studies," J. Antibiotic, 30, (6), 450-454, (1977).

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