Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Oxidoreductases
Patent
1997-05-09
1999-12-14
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Oxidoreductases
424 941, 435183, 435189, A61K 3844
Patent
active
060013532
ABSTRACT:
The present invention relates generally to methods of inducing contraceptive or abortive effects via modulation of levels of circulating hormones via administration of an enzyme, pharmaceutical compositions achieving such effects, antibody substances immunoreactive to said enzyme and related substances, and methods for screening for the predisposition of spontaneous abortions
REFERENCES:
patent: 4006227 (1977-02-01), Gallegos et al.
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 5594104 (1997-01-01), Basinski et al.
Albarracin et al., "Prolactin Action on Leuteal Protein Expression in the Corpus Luteum," Endocrinology, 129(4): 1821-1830 (1991).
Albarracin et al., "Identification of a Major Prolactin-Regulated Protein as 20.alpha.-Hydroxysteroid Dehydrogenase: Coordinate Regulation of Its Activity, Protein Content, and Messenger Ribonucleic Acid Expression," Endocrinology, 134(6):2453-2460 (1994).
Azhar et al., "Characterization of insulin receptor kinase activity and autophosphorylation in different skeletal muscle types," Am. J. Physiol., 260:E1-E7 (1991).
Azhar et al., "Calcium-Activated, Phospholipid-Dependent Protein Kinases from Rat Liver: Subcellular Distribution, Purification, and Characterization of Multiple Forms," Biochemistry, 26:7047-7057 (1987).
Bairoch, A., "PROSITE: a dictionary of sites and patterns in proteins," Nucleic Acids Res., 20(Supplement):2013-2018 (1992).
Chomzynski and Sacchi, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction," Anal. Biochem., 162:156-159 (1987).
Current Protocols in Molecular Biology, Eds., Ausubel et al., Wiley and Sons, New York, pp. 16.12.1-16.14.13 (1996).
De La Llosa-Hermier et al., "20-.alpha.-Hydroxysteroid dehydrogenase from pseudopregnant rat ovary: Obtention and characterization of a monoclonal antibody against the enzyme activity," Biochimie, 74:1117-1120 (1992).
Duan et al., "Characterization of 20.alpha.-Hydroxysteroid Dehydrogenase Expressed in Bacterial and Insect Cell Systems," The Endocrine Society, 77th Annual Meeting, p. 143 (1995) (Abstract P1-124).
Gibori et al., "The Role of Estrogen in the Regulation of Luteal Progesterone Secretion in the Rat After Day 12 of Pregnancy," Endocrinology, 100:1483-1495 (1977).
Hakes and Dixon, "New Vectors for High Level Expression of Recombinant Proteins in Bacteria," Anal. Biochem., 202:293-298 (1992).
Hashimoto and Wiest, "Correlation of the Secretion of Ovarian Steroids with Function of a Single Generation of Corpora Lutea in the Immature Rat," Endocrinology, 84:873-885 (Apr., 1969).
Iwata et al., "The Purification and Properties of Aldose Reductase from Rat Ovary," Arch. Biochem. Biophys., 282(1):70-77 (Oct., 1990).
Jones and Hsueh, "Direct Stimulation of Ovarian Progesterone-metabolizing Enzyme by Gonadotropin-releasing Hormone in Cultured Granulosa Cells," J. Biol. Chem., 256(3):1248-1254 (Feb., 1981).
Kuhn and Briley, "The Roles of Pregn-5-ene-3.beta.,20.alpha.-diol and 20.alpha.-Hydroxy Steroid Dehydrogenase in the Control of Progesterone Synthesis preceding Parturition and Lactogenesis in the Rat," Biochem. J., 117:193-201 (1970).
Lacy et al., "Molecular Cloning and Expression of an Abundant Rabbit Ovarian Protein with 20.alpha.-Hydroxysteroid Dehydrogenase Activity," Molecular Endocrinology, 7(1):58-66 (1933).
Mao et al., "Isolation and Characterization of a Rat Luteal cDNA Encoding 20.alpha.-Hydroxysteroid Dehydrogenase," Biochem. Biophys. Res. Comm., 201(3):1289-1295 (Jun. 30, 1994).
Mao et al., "Expression, Purification and Characterization of the Rat Luteal 20.alpha.-Hydroxysteroid Dehydrogenase," Endocrinology, 138(1):182-190 (1997).
Mitchell et al., "Selectivity of nonsteroid antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase," Proc. Nat'l Acad. Sci., USA, 90:11693-11697 (Dec., 1994).
Miura et al., "Molecular Cloning of cDNA for Rat Ovarian 20.alpha.-Hydroxysteroid Dehydrogenase (HSD1)," Biochem. J., 299:561-567 (1994).
Mori and Wiest, "Purification of Rat Ovary 20.alpha.-Hyroxysteroid Dehydrogenase by Affinity Chromatography," J. Steroid Biochem., 11:1443-1449 (1979).
Naito et al., "In vitro Secretion of Progestins by Rat Luteal Cells and their 20.alpha.-Hydroxysteroid Dehydrogenase Activity," Endocrinology Jpn., 33(1):43-50 (Feb., 1986).
Noda et al., "Purification and characterization of rat ovarian 20.alpha.-hydroxysteroid dehydrogenase," Biochim. et Biophys. Acta, 1079:112-118 (1991).
Pearson and Lipman, "Improved tools for biological sequence comparison," Proc. Nat'l Acad. Sci., USA, 85:2444-2448 (Apr., 1988).
Pongsawasdi and Anderson, "Kinetic Studies of Rat Ovarian 20.alpha.-Hydroxysteroid Dehydrogenase," Biochim. et Biophys. Acta., 799:51-58 (1984).
Raz and Needleman, "Differential modification of cyclo-oxygenase and peroxidase activities of prostaglandin endoperoxidase synthase by proteolytic digestion and hydroperoxides," Biochem. J., 269:603-607 (1990).
Rodway and Kuhn, "Hormonal Control of Luteal 20.alpha.-Hydroxy Steroid Dehydrogenase and .increment..sup.5 -3.beta.-Hydroxy Steroid Dehydrogenase during Luteolysis in the Pregnant Rat," Biochem. J., 152:433-443 (1975).
Simonson and Herman, "Protein Kinase C and Protein Tyrosine Kinase Activity Contribute to Mitogenic Signaling by Endothelin-1," J. Biol. Chem., 268(13):9347-9357 (May, 1993).
Srivastava et al., "Antireproductive Effect of Recombinant 20.alpha. Hydroxysteroid Dehydrogenase During Pregnancy," 10th International Congress of Endocrinology (Abstract) (1996).
Talwalker et al., "Maintenance of pregnancy in spayed rats with 20.alpha.-hydroxypregn-4-ene-3-one and 20-beta-hydroxypregn-4-ene-3-one," Nature, 209(18):86-87 (Jan. 1, 1966).
Webb and Summer, "Expression of Proteins Using Recombinant Baculoviruses," Technique-A Journal of Methods in Cell and Molecular Biology, 2(4):173-188 (Aug., 1990).
Weist, W.G., "On the Function of 20.alpha.-Hydroxypregn-4-en-3-one During Parturition in the Rat," Endocrinology, 83:1181-1184 (1968).
Wiest et al., "Progesterone Catabolism in the Rat Ovary: A Regulatory Mechanism for Progestational Potency During Pregnancy," Endocrinology, 82:844-859 (Apr., 1968).
Chan Christina Y.
Nolan Patrick J.
The Board of Trustees of The Univeristy of Illinois
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