20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals

Details 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals

1990-10-19

1993-03-02

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549465, A61K 3134, A61K 31557, C07D307937

Patent

active

051909731

ABSTRACT:
The invention concerns 20-alkyl-7-oxoprostacyclin derivatives of general Formula I ##STR1## wherein R.sub.1 is the residue OR.sub.3 where R.sub.3 means hydrogen or alkyl of 1-10 carbon atoms optionally substituted by halogen, phenyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -dialkylamino; cycloalkyl, aryl or a heterocyclic residue, or the residue NHR.sub.4 where R.sub.4 means hydrogen or an alkanoyl or alkanesulfonyl residue of respectively 1-10 carbon atoms,

REFERENCES:
patent: 4364950 (1982-12-01), Shuballa et al.
patent: 4466969 (1984-08-01), Nicholson et al.
van Dorp et al., Prostaglandins, vol. 16(6), pp. 953-956.

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