2α-Methyl and 2β-methyl analogs of...

Details 2α-Methyl and 2β-methyl analogs of... 2α-Methyl and 2β-methyl analogs of...

2007-07-10

2007-07-10

Qazi, Sabiha N. (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

C552S653000

Reexamination Certificate

active

11283124

ABSTRACT:
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26,27-trinor-(20S)-1α-hydroxyvitamin D3and pharmaceutical uses therefor. These compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. These compounds also have little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. These compounds may also be used for the treatment or prevention of obesity.

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patent: 6992074 (2006-01-01), DeLuca et al.
patent: 7094916 (2006-08-01), DeLuca et al.
patent: WO 02094247 (2002-11-01), None

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