2″ oxo-voruscharin and derivatives thereof

Details 2″ oxo-voruscharin and derivatives thereof 2″ oxo-voruscharin and derivatives thereof

2003-10-09

2008-01-22

Badio, Barbara P. (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C540S061000

Reexamination Certificate

active

07320971

ABSTRACT:
2″ oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″ oxo-voruscharin compound or derivatives thereof. The disclosed 2″ oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.

REFERENCES:
patent: 5645988 (1997-07-01), Vande Woude et al.
Desheesh et al., “Glycosidic cardenolides. I. Chemistry of isolation and purification from Calotropis procera plant.” Alexandria Science Exchange, vol. 21(3), pp. 221-228, 2000. Abstract only.
Cheung, et al. “Cardenolide Glycosides of the Asclepiadaceae. New Glycosides fromAsclepias fruticosaand the Stereochemistry of Uscharin, Voruscharin and Calotoxin,”Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, (1972-1999) (1983), (12), pp. 2827-2835.
International Search Report, completed Feb. 23, 2004 and issued to a related foreign application.

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