Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2011-07-19
2011-07-19
Badio, Barbara P (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C540S061000
Reexamination Certificate
active
07981875
ABSTRACT:
Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer.
REFERENCES:
patent: 5645988 (1997-07-01), Vande Woude et al.
patent: WO 98/52562 (1998-11-01), None
Desheesh, et al. “Glycosidic Cardenolides. I. Chemistry of Isolation and Purification from Calotropis procera Plant,”Alexandria Science Exchange, vol. 21, No. 3, pp. 221-228, 2000. Abstract only.
Cheung, et al. “Cardenolide Glysides of the Asclepiadaceae. New Glycosides fromAsclepias fruticosaand the Sterochemistry of Uscharin, Voruscharin and Calotoxin,”Journal of ChemicalSociety, Perkin Transactions 1: Organic and Bio-Organic Chemistry, (1972-1999), (1983),(12), pp. 2827-2835.
Braekman Jean-Claude
Darro Francis
Dewelle Janique
Guissou Pierre
Kiss Robert
Badio Barbara P
Knobbe Martens Olson & Bear LLP
Unibioscreen S.A.
Universite Libre De Bruxelles
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