2′-substituted 1,1′-biphenyl-2-carboxamides,...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S334000, C546S336000, C546S337000, C514S357000

Reexamination Certificate

active

07982045

ABSTRACT:
Compounds of the formula I,in which R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel and antiarrythmic active compounds, in particular for the treatment and prophylaxis of atrial arrythmias, e.g. atrial fibrillation (AF), or atrial flutter.

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patent: 98/18476 (1998-05-01), None
Brandmeier, et al., Antiparallel beta-Sheet Conformation in Cyclopeptides Containing a Pseudo-amino Acid with a Biphenyl Moiety, Helvetica Chima Acta; 77; 1994; pp. 70-85.
Dorwald, F.A., Side reactions in organic synthesis, Wiley-VCH, Weinheim, 2005; p. IX of Preface.
Caplus AN 2001:608248 English Abstract, Chemstar Product List RN# 328284 May 16, 2001.
Knobloch, et al., Antiarrhythmic Effects of KV1.5 Channel Blockers . . . , Abstract, Thorac Cardiovasc Surg. 2002; Feb. 19, 2002.
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Geurtin, K.,Caplus English abstract DN 127:136073, (1997).

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