Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2003-11-17
2010-11-02
Lucas, Zachariah (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S006120, C536S028100, C536S028200, C536S027100, C514S049000, C514S025000, C514S050000, C514S04400A
Reexamination Certificate
active
07824851
ABSTRACT:
The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from seine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (Sequence ID No. 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
REFERENCES:
patent: 3116282 (1963-12-01), Hunter
patent: 3480613 (1969-11-01), Walton
patent: 3798209 (1974-03-01), Witkowski et al.
patent: 3891623 (1975-06-01), Vorbruggen et al.
patent: 4022889 (1977-05-01), Bannister et al.
patent: 4058602 (1977-11-01), Beisler et al.
patent: RE29835 (1978-11-01), Witkowski et al.
patent: 4209613 (1980-06-01), Vorbruggen et al.
patent: 4239753 (1980-12-01), Skulnick et al.
patent: 4294766 (1981-10-01), Schmidt et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4605659 (1986-08-01), Verheyden et al.
patent: 4689404 (1987-08-01), Kawada et al.
patent: 4754026 (1988-06-01), Kawada et al.
patent: 4814477 (1989-03-01), Wijnberg et al.
patent: 4880784 (1989-11-01), Robins et al.
patent: 4952740 (1990-08-01), Juge et al.
patent: 4957924 (1990-09-01), Beauchamp
patent: 5034394 (1991-07-01), Daluge
patent: 5122517 (1992-06-01), Vince et al.
patent: 5149794 (1992-09-01), Yatvin et al.
patent: 5157027 (1992-10-01), Biller et al.
patent: 5194654 (1993-03-01), Hostetler et al.
patent: 5200514 (1993-04-01), Chu
patent: 5223263 (1993-06-01), Hostetler et al.
patent: 5246924 (1993-09-01), Fox et al.
patent: 5256641 (1993-10-01), Yatvin et al.
patent: 5256797 (1993-10-01), Chou et al.
patent: 5322955 (1994-06-01), Matsumoto et al.
patent: 5371210 (1994-12-01), Chou
patent: 5372808 (1994-12-01), Blatt et al.
patent: 5391769 (1995-02-01), Matsumoto et al.
patent: 5401861 (1995-03-01), Chou
patent: 5411947 (1995-05-01), Hostetler et al.
patent: 5463092 (1995-10-01), Hostetler et al.
patent: 5539116 (1996-07-01), Liotta et al.
patent: 5543389 (1996-08-01), Yatvin et al.
patent: 5543390 (1996-08-01), Yatvin et al.
patent: 5543391 (1996-08-01), Yatvin et al.
patent: 5554728 (1996-09-01), Basava et al.
patent: 5565438 (1996-10-01), Chu et al.
patent: 5567688 (1996-10-01), Chu et al.
patent: 5587362 (1996-12-01), Chu et al.
patent: 5606048 (1997-02-01), Chou et al.
patent: 5676942 (1997-10-01), Testa et al.
patent: 5696277 (1997-12-01), Hostetler et al.
patent: 5738845 (1998-04-01), Imakawa
patent: 5744600 (1998-04-01), Mansuri et al.
patent: 5750676 (1998-05-01), Vorbruggen et al.
patent: 5763418 (1998-06-01), Matsuda et al.
patent: 5780617 (1998-07-01), Van den Bosch et al.
patent: 5789608 (1998-08-01), Glazier
patent: 5821357 (1998-10-01), Chou et al.
patent: 5830455 (1998-11-01), Valtuena et al.
patent: 5849696 (1998-12-01), Chretien et al.
patent: 5908621 (1999-06-01), Glue et al.
patent: 5928636 (1999-07-01), Alber et al.
patent: 5942223 (1999-08-01), Bazer et al.
patent: 5977061 (1999-11-01), Holy et al.
patent: 5977325 (1999-11-01), McCarthy et al.
patent: 5980884 (1999-11-01), Blatt et al.
patent: 6002029 (1999-12-01), Hostetler et al.
patent: 6063628 (2000-05-01), Loeb et al.
patent: 6140310 (2000-10-01), Glazier
patent: 6153594 (2000-11-01), Borretzen et al.
patent: 6156501 (2000-12-01), McGall et al.
patent: 6172046 (2001-01-01), Albrecht
patent: 6248878 (2001-06-01), Matulic-Adamic et al.
patent: 6252060 (2001-06-01), Hostetler
patent: 6271212 (2001-08-01), Chu et al.
patent: 6277830 (2001-08-01), Ganguly et al.
patent: 6312662 (2001-11-01), Erion et al.
patent: 6340690 (2002-01-01), Bachand et al.
patent: 6348587 (2002-02-01), Schinazi et al.
patent: 6369040 (2002-04-01), Acevedo et al.
patent: 6395716 (2002-05-01), Gosselin et al.
patent: 6436437 (2002-08-01), Yatvin et al.
patent: 6444652 (2002-09-01), Gosselin et al.
patent: 6448392 (2002-09-01), Hostetler et al.
patent: 6455508 (2002-09-01), Ramasamy et al.
patent: 6458772 (2002-10-01), Zhou et al.
patent: 6458773 (2002-10-01), Gosselin et al.
patent: 6472373 (2002-10-01), Albrecht
patent: 6495677 (2002-12-01), Ramasamy et al.
patent: 6566344 (2003-05-01), Gosselin et al.
patent: 6566365 (2003-05-01), Storer
patent: 6569837 (2003-05-01), Gosselin et al.
patent: 6573248 (2003-06-01), Ramasamy et al.
patent: 6596700 (2003-07-01), Sommadossi et al.
patent: 6599887 (2003-07-01), Hostetler et al.
patent: 6605614 (2003-08-01), Bachand et al.
patent: 6642206 (2003-11-01), Ramasamy et al.
patent: 6660721 (2003-12-01), Devos et al.
patent: 6748161 (2004-06-01), Ko et al.
patent: 6752981 (2004-06-01), Erion et al.
patent: 6777395 (2004-08-01), Bhat et al.
patent: 6784161 (2004-08-01), Ismaili et al.
patent: 6784166 (2004-08-01), Devos et al.
patent: 6787526 (2004-09-01), Bryant et al.
patent: 6812219 (2004-11-01), LaColla et al.
patent: 6815542 (2004-11-01), Hong et al.
patent: 6831069 (2004-12-01), Tam et al.
patent: 6833361 (2004-12-01), Hong et al.
patent: 6846810 (2005-01-01), Martin et al.
patent: 6875751 (2005-04-01), Imbach et al.
patent: 6908924 (2005-06-01), Watanabe et al.
patent: 6911424 (2005-06-01), Schinazi et al.
patent: 6914054 (2005-07-01), Sommadossi et al.
patent: 6927291 (2005-08-01), Jin et al.
patent: 6946115 (2005-09-01), Erion et al.
patent: 6946450 (2005-09-01), Gosselin et al.
patent: 6949522 (2005-09-01), Otto et al.
patent: 6965033 (2005-11-01), Jiang et al.
patent: 7056895 (2006-06-01), Ramasamy et al.
patent: 7094770 (2006-08-01), Watanabe et al.
patent: 7101861 (2006-09-01), Sommadossi et al.
patent: 7105493 (2006-09-01), Sommadossi et al.
patent: 7105499 (2006-09-01), Carroll et al.
patent: 7125855 (2006-10-01), Bhat et al.
patent: 7144868 (2006-12-01), Roberts et al.
patent: 7148206 (2006-12-01), Sommadossi et al.
patent: 7151089 (2006-12-01), Roberts et al.
patent: 7157434 (2007-01-01), Keicher et al.
patent: 7157441 (2007-01-01), Sommadossi et al.
patent: 7163929 (2007-01-01), Sommadossi et al.
patent: 7169766 (2007-01-01), Sommadossi et al.
patent: 7202224 (2007-04-01), Eldrup et al.
patent: 2002/0019363 (2002-02-01), Ismaili et al.
patent: 2002/0035085 (2002-03-01), Sommadossi et al.
patent: 2002/0052345 (2002-05-01), Erion et al.
patent: 2002/0055473 (2002-05-01), Ganguly et al.
patent: 2002/0055483 (2002-05-01), Watanabe et al.
patent: 2002/0095033 (2002-07-01), Ramasamy et al.
patent: 2002/0099072 (2002-07-01), Bachand et al.
patent: 2002/0127203 (2002-09-01), Albrecht
patent: 2002/0147160 (2002-10-01), Bhat et al.
patent: 2002/0156030 (2002-10-01), Ramasamy et al.
patent: 2002/0173490 (2002-11-01), Jiang et al.
patent: 2002/0198171 (2002-12-01), Schinazi et al.
patent: 2003/0008841 (2003-01-01), Devos et al.
patent: 2003/0028013 (2003-02-01), Wang et al.
patent: 2003/0039630 (2003-02-01), Albrecht
patent: 2003/0050229 (2003-03-01), Sommadossi et al.
patent: 2003/0053986 (2003-03-01), Zahm
patent: 2003/0055013 (2003-03-01), Brass
patent: 2003/0060400 (2003-03-01), LaColla et al.
patent: 2003/0083306 (2003-05-01), Imbach et al.
patent: 2003/0083307 (2003-05-01), Devos et al.
patent: 2003/0087873 (2003-05-01), Stuyver et al.
patent: 2003/0124512 (2003-07-01), Stuyver
patent: 2003/0220290 (2003-11-01), Gosselin et al.
patent: 2003/0225028 (2003-12-01), Gosselin et al.
patent: 2003/0225029 (2003-12-01), Stuyver
patent: 2003/0225037 (2003-12-01), Storer et al.
patent: 2003/0236216 (2003-12-01), Devos et al.
patent: 2004/0002476 (2004-01-01), Stuyver et al.
patent: 2004/0002596 (2004-01-01), Hong et al.
patent: 2004/0006002 (2004-01-01), Sommadossi et al.
patent: 2004/0023921 (2004-02-01), Hong et al.
patent: 2004/0059104 (2004-03-01), Cook et al.
patent: 2004/0063622 (2004-04-01), Sommadossi et al.
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0067901 (2004-04-01), Bhat et al.
patent: 2004/0072788 (2004-04-01), Bhat et al
Bichko Vadim
LaColla Paolo
Qu Lin
Sommadossi Jean-Pierre
Standring David
Humphrey Louise
Idenix Pharmaceuticals Inc.
Jones Day
Lucas Zachariah
Universita Degli Studi Di Cagliari
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