2′-arabino-fluorooligonucleotide...

Details 2′-arabino-fluorooligonucleotide... 2′-arabino-fluorooligonucleotide...

2011-08-02

2011-08-02

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S026100, C536S028100, C536S028400, C536S027810, C536S027600, C514S042000

Reexamination Certificate

active

07989603

ABSTRACT:
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.

REFERENCES:
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patent: 01104092 (1989-04-01), None
patent: WO 91/10671 (1991-07-01), None
STN Abstract of Morisawa et al., JP 0-1104092 A, Apr. 21, 1989.
Morisawa et al..; JP 01104092 A, Apr. 21, 1989, English Translation.
Gryaznov et al.,Nucleic Acids Res., 24(8):1508-1514 (1996).
Ikeda et al.,Nucleic Acids Res., 26(9):2237-2244 (1998).
Kawasaki et al.,J. Med. Chem., 36:831-841 (1993).
Schultz and Gryaznov,Nucleic Acids Res., 24(15):2966-2973 (1996).
Skorski et al.,PNAS, 94:3966-3971 (1997).
International Search Report for PCT/US01/01918, Geron Corporation, May 29, 2001.
Schultz, R. and Gryaznov, S.,Tetrahedron Letters, 41:1895-1899 (2000).

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