2′ and 3′-substituted cyclobutyl nucleoside...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S263400, C514S274000, C544S244000, C544S276000, C544S277000, C544S312000, C544S313000, C544S314000, C544S317000

Reexamination Certificate

active

07495006

ABSTRACT:
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans.

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Hayashi, S., et al., “Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro,” (1990)Antimicrob. Agents Chemother., 34(2):287-294 (Feb. 1990).
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Maruyama, T., et al., “Synthesis and antiviral activities of carbocyclic oxetanocin analogues,”Chem. Pharm. Bull. (Tokyo), 38(10):2719-2725 (Oct. 1990).

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