2-Ureido-thiazole derivatives, process for their...

Details 2-Ureido-thiazole derivatives, process for their... 2-Ureido-thiazole derivatives, process for their...

2005-03-08

2005-03-08

Gerstl, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06863647

ABSTRACT:
Compounds which are 2-ureido-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group optionally further substituted, selected from: i) straight or branched C1-C6alkyl; ii) C3-C6cycloalkyl; iii) aryl or arylalkyl with from 1 to 6 carbon atoms within the straight or branched alkyl chain; R1is an optionally substituted group selected from: i) straight or branched C1-C6alkyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring; iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 6 carbon atoms within the straight or branched alkyl chain; R2is hydrogen, a straight or branched C1-C6alkyl or C2-C4alkenyl or alkynyl group; or, taken together with the nitrogen atom so which they are bonded, R1and R2form a substituted or unsubstituted group selected from: i) an optionally benzocondensed or bridged 5 to 7 membered heterocycle; or ii) a 9 to 11 membered spiro-heterocyclic compound; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.

REFERENCES:
patent: 6187799 (2001-02-01), Wood et al.
patent: 168393 (1973-11-01), None
patent: 209839 (1989-04-01), None
patent: WO 9740028 (1997-10-01), None

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