2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-i

Details 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-i 2-Trifluoromethyl-3-quinoline carboxamides, analgesic and anti-i

1979-11-27

1981-11-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424258, 544328, 544331, 546156, A61K 3147, C07D21556

Patent

active

042998310

ABSTRACT:
Novel 3-quinoline carboxamides of the formula ##STR1## wherein X' is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, halogen, straight or branched alkyl and alkoxy of 1 to 5 carbon atoms, --CF.sub.3, --SCF.sub.3 and --OCF.sub.3, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R.sub.2 ' is selected from the group consisting of thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl, isoxazolyl, imidazolyl, pyrimidyl and tetrazolyl, all optionally substituted with alkyl of 1 to 4 carbon atoms and phenyl optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 4 carbon atoms, --CF.sub.3, --NO.sub.2 and halogen and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and novel intermediates and process for their preparation.

REFERENCES:
patent: 3992540 (1976-11-01), Clemence
patent: 4044138 (1977-08-01), Curran et al.
patent: 4107310 (1978-08-01), Allais
Dey, et al., J. Het. Chem. vol. 2, No. 2, pp. 113-119 (1965).

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