2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives

Details 2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives 2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives

1981-07-17

1983-01-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548437, C07D20990, A61K 3140

Patent

active

043691889

ABSTRACT:
Herein are disclosed compounds of the formula ##STR1## in which R.sup.1 is hydrogen, lower alkyl or --(CH.sub.2).sub.m --NR.sup.4 R.sup.5 wherein m is an integer from 2 to 6 and R.sup.4 and R.sup.5 each is hydrogen or lower alkyl; R.sup.2 is hydrogen, bromo or chloro; and R.sup.3 is hydrogen or halo; with the requirement that when R.sup.2 is bromo or chloro, then R.sup.3 is bromo or chloro or a therapeutically acceptable salt thereof. The compounds inhibit lens aldose reductase in a diabetic mammal.

REFERENCES:
patent: 3386986 (1968-06-01), Brach
patent: 3755353 (1973-08-01), Baumann et al.
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 3853911 (1974-12-01), Scnefczik
patent: 4080331 (1978-03-01), Brack
patent: 4254108 (1981-03-01), Sestanj
patent: 4254109 (1981-03-01), Sestanj
Karishin et al.; Chem. Abs., vol. 88:21753e (1978).
Rozhinskii et al.; Chem. Abs., vol. 78:29537b (1973).
Vul'fson et al.; Chem. Abs., vol. 71:82627n (1968).
Karishin et al.; Chem. Abs., vol. 89:163333n (1978).
Dutt; J. Chem. Soc., 224 (1923).
Dvornik et al.; Science, vol. 182, p. 1146 (1973).
Pechka et al.; Chem. Abs., vol. 87:184310b (1977).

Affiliated with

Also associated with

Rating

2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-137230