2-thioxo-tetrahydropyrimidin-4-one derivatives

Details 2-thioxo-tetrahydropyrimidin-4-one derivatives 2-thioxo-tetrahydropyrimidin-4-one derivatives

1997-02-27

1998-09-15

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544309, C07D23956, A61K 31505

Patent

active

058078649

ABSTRACT:
This invention relates to the use of 2-thioxotetrahydropyrimidin-4-one derivatives to increase HDL cholesterol concentration and as therapeutic compositions for treating atherosclerotic conditions such as dyslipoproteinemias and coronary heart disease. The compounds of this invention are represented by the formula: ##STR1## wherein: R is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or C.sub.2 -C.sub.6 alkynyl; and

REFERENCES:
patent: 4588729 (1986-05-01), Teranishi
patent: 4927451 (1990-05-01), Brouwer
Iwao, Chemical Abstracts, vol. 103, entry 178225 (1985).
Avaeva et al., Chemical Abstracts, vol. 88, entry 90023 (197).
Dembecki et al., vol. 85, entry 32949 (1976).

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