2-thioindoles (selenoindoles) and related disulfides (selenides)

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514339, 514365, 514369, 514372, 514397, 514418, 514419, 546256, 5462697, 5462744, 5462777, 5462707, 546113, 548206, 548214, 548181, 548460, 548467, 548468, 548485, 548486, 5483121, A61K 3140, C07D20910

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active

055568742

ABSTRACT:
2-Thioindoles (2-selenoindoles) and analogous 2-indolinethione (2-indolineselenone) and polysulfide (selenide) compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds, and methods for inhibiting protein kinase dependent disease in a mammal or treating aberrant cell growth in a mammal, using said compositions, are disclosed.

REFERENCES:
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CA 105 = 172217d Studies . . . acid. Barton et al., p. 723, 1986.
CA 112 = 158892h Reaction . . . bromide. Crich et al., p. 781, 1990.
Tetrahedron, vol. 42, No. 21, p. 5879-5886, Takase et al., 1986.
Hino et al., "Chem. Pharm. Bull." 21, 2739-2748 (1973).
Kobayashi et al., "Yakugaku Zasshi" 89, 58-63 (1969).
Takase et al., "Tetrahedron", 42, 5879 (1986).
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Palmisano et al., "Tet Lett" 31, 7229 (1990).
CA91=5064n Cyclization . . . halides. Kost et al., p. 475, 1979.
CA105=152874n Thermal . . . indoline-2-thiones. Baudin et al., p. 678, 1986.
CA114=121939u Synthesis . . . triazines. Nesterova et al., p. 755, 1991.

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