2-thioindoles (selenoindoles) and related disulfides (selenides)

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514418, 514339, 514365, 514369, 514397, 548181, 5483121, 548460, 548461, 548462, 548486, 546273, A61K 3140, C07D20904

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active

054648610

ABSTRACT:
2-Thioindoles (2-selenoindoles) and analogous 2-indolinethione (2-indolineselenone) and polysulfide (selenide) compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds, and methods for inhibiting protein kinase dependent disease in a mammal or treating aberrant cell growth in a mammal, using said compositions, are disclosed.

REFERENCES:
patent: 5137909 (1992-08-01), Miura et al.
CA 105=172217d Studies . . . acid. Barton et al., p. 723, 1986.
CA 112=158892h Reaction . . . bromide. Crich et al., p. 781, 1990.
Tetrahedron, vol. 42, No. 21, p. 5879-5886, Takase et al., 1986.
Bulletin de la Societe Chimique de France, vol. 1, 1987, pp. 181-188.
Tetrahedron, vol. 42, No. 21, pp. 5879-5886, 1986.

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