2-thio or 2-oxo flavopiridol analogs

Details 2-thio or 2-oxo flavopiridol analogs 2-thio or 2-oxo flavopiridol analogs

1997-05-01

1998-12-15

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514320, 514422, 540596, 546196, 548525, C07D40504, A61K 3135

Patent

active

058497331

ABSTRACT:
Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof, wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, m and n are as defined in the disclosure. The compounds of formula I are protein kinase inhibitors and are useful in the treatment of proliferative diseases.

REFERENCES:
patent: 4900727 (1990-02-01), Kattige et al.
patent: 5284856 (1994-02-01), Naik et al.
Kaur et al., Growth Inhibition with Reversible Cell Cycle Arrest of Carcinoma cells by Flavone L86-8275, J. of the National Cancer Institute, vol. 84, No. 22, pp. 1736-1740, Nov. 1992.

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