Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-07-12
2005-07-12
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S092000, C544S091000
Reexamination Certificate
active
06916808
ABSTRACT:
The use of a compound, comprising formula (I) or a salt, ester, amide of prodrug thereof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is an optionally substituted 6-membered aromatic or heteroaromatic ring; and R1is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups
REFERENCES:
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patent: WO 00/40569 (2000-07-01), None
NIDDK Weight—control Information Network at <http://www.niddk.nih.gov/health
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Krantz et al., “Design and synthesis of 4H-3, 1-benzoxazin-4-ones as potent alternate inhibitors of human leukocyte elastase”,J. Med. Chem.33:464-479, 1990.
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Copy of International Search Report for PCT/GB01/00171.
Downham Robert
Dunk Christopher Robert
Hodson Harold Francis
Palmer Richard Michael John
Alizyme Therapeutics Limited
Berch Mark L.
Choate Hall & Stewart LLP
Habte Kahsay
Herschbach Jarrell Brenda
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