2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation a

Details 2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation a 2-(tetrazol-5-yl)-1,1'-biphenyl derivatives, their preparation a

1992-12-29

1994-12-06

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548252, 548253, C07D25704, C07D40310

Patent

active

053712331

ABSTRACT:
Compounds corresponding to the formula (I) ##STR1## in which X represents dibromomethyl, formyl, (C.sub.1-4)alkyl, or a group CH(OR.sub.5).sub.2 or CH(OH)OR.sub.5, wherein the or each R.sub.5 is hydrogen (C.sub.1-3)alkyl or the two R.sub.5 's in the case of CH(OR.sub.5).sub.2 are linked to provide a 1,3-dioxolane or 1,3-dioxane ring, and Y represents hydrogen, 1,1-dimethylethyl, triphenylmethyl, trimethylstannyl, tributylstannyl, (1,1-dimethylethyl)dimethylsilyl, (1,1-dimethylethyl)diphenylsilyl, 2-cyanoethyl, or a group CH.sub.2 OR.sub.6 wherein R.sub.6 is methyl, phenylmethyl, 1,1-dimethylethyl, 2,2,2-trichloroethyl, benzyloxycarbonyl or 2,2,2-trichloroethyloxycarbonyl, Y being in position 1 or 2 on the tetrazole ring. The compounds of formula (I) are useful as intermediates in the synthesis of compounds possessing therapeutic activity.

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patent: 5130439 (1992-07-01), Lo et al.
Journal of the Chemical Society, Perkin Transaction No. 2, No. 12, 1979, London, pp. 1670-1674.

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