2-substituted trimethylpyrazine derivatives as inhibitors of pla

Details 2-substituted trimethylpyrazine derivatives as inhibitors of pla 2-substituted trimethylpyrazine derivatives as inhibitors of pla

1989-04-11

1990-12-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 514255, 544336, 544357, 544359, A61K 31495, A61K 31335, C07D24112

Patent

active

049786628

ABSTRACT:
Novel 2-substituted trimethylpyrazine derivatives of the formula: ##STR1## wherein R is alkylamino, 4-methyl-1-piperazinyl, piperidino, morpholino or 2-trimethylpyrazinepropenyl.
These novel 2-substituted trimethylpyrazine derivatives exhibit, at very low concentrations, activity as inhibitors of platelet function and as promoters of blood pressure reduction.

REFERENCES:
patent: 4620004 (1986-10-01), Sanders et al.
Yang, Chu-Yao, Chemical Abstracts, 95(15): 132813p, p. 667, Oct. 12, 1981.
Joshi, S. C., Chemical Abstracts, 99(11): 88170h, p. 569, Sep. 12, 1983.
Ohta, Akihiro, Chemical Abstracts, 102(1): 6421j, p. 584, Jan. 7, 1985.
Chemical Abstracts Registry Handbook, 1981 Supplement, 79074-40-1.

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