2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-di

Details 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-di 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-di

1986-04-21

1988-03-01

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514223, 514228, 514234, 514236, 514252, 540601, 544 581, 544 584, 544 586, 544 82, 544121, 544122, 544123, 544315, 544316, 544318, A61K 31505, A61K 3155, C07D23922, C07D41714

Patent

active

047286520

ABSTRACT:
1,4-Dihydropyrimidines of the formula ##STR1## wherein X is sulfur or oxygen and R.sub.4 is aryl or heterocyclo and disclosed. These compounds are useful as cardiovacular agents, particularly anti-hypertensive agents, due to their vasodilator activity.

REFERENCES:
patent: 3488359 (1970-01-01), Bossert et al.
patent: 4048171 (1977-09-01), Bossert et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4609494 (1986-09-01), Baldwin et al.
patent: 4640922 (1987-02-01), Cho et al.
patent: 4675321 (1987-06-01), Baldwin et al.
patent: 4683234 (1987-07-01), Cho et al.
patent: 4684655 (1987-08-01), Atwal
patent: 4684656 (1987-08-01), Atwal
patent: 4689414 (1987-08-01), Atwal
Medicinal Chemistry, Burger edit., 2nd ed., 1960, pp. 565-571, 579-581, 600, and 601.
Merck Index, 10th Edition, 6374, Nifedipine.
Iwanami et al., Chem. Abst., vol. 86, 43570d (1977).
Zidermane et al., Chem. Abst., vol. 75, 47266e.
Goerlitzer et al., Chem. Abst., vol. 96, 8550lu (1982).
Stoltefuss et al., Chem. Abst., vol. 101, 55110v (1984).
Goerlitzer et al., Arch. Pharm. 314, 938-949 (1981).

Affiliated with

Also associated with

Rating

2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-di does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-di, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-di will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-998088