2-Substituted thio carbapenem derivatives

Details 2-Substituted thio carbapenem derivatives 2-Substituted thio carbapenem derivatives

1982-02-03

1984-10-16

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544182, 544198, 544209, 544215, 544219, 544298, 544316, 544319, 546272, 548252, 548253, 548336, 2602452T, 2602452R, C07D48704

Patent

active

044776624

ABSTRACT:
A process for the preparation of an antibacterially active compound of the formula (I): ##STR1## and salts and esters thereof wherein R.sup.1 and R.sup.2 independently are hydrogen or an organic group, and R.sup.3 is an organic group bonded via a carbon atom to the sulphur atom, which comprises reacting a compound of the formula (II): ##STR2## wherein R.sup.4 is an organic group different to R.sup.3 and R.sup.a is hydrogen or a carboxy-blocking group, with a thiol R.sup.3 SH or reactive derivative thereof. In addition certain compounds within the formula (II) are novel and useful antibacterial agents in their own right.

REFERENCES:
patent: 4337199 (1982-06-01), Yoshioka et al.

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