2-(substituted sulfamyl)-6-nitrobenzoic acid amides and pharmace

Details 2-(substituted sulfamyl)-6-nitrobenzoic acid amides and pharmace 2-(substituted sulfamyl)-6-nitrobenzoic acid amides and pharmace

1985-11-06

1987-03-03

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

560 13, 562430, 564 87, 514535, 514562, A61K 3118, C07C14378

Patent

active

046475885

ABSTRACT:
2-(Substituted sulfamyl) derivatives of 6-nitrobenzoic acid wherein at least one of the sulfamyl substituents is a basic substituent selected from amino-(lower alkyl), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl) are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 3017427 (1962-01-01), Hamor
patent: 4113463 (1978-09-01), Oshio et al.

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