Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-05-30
1990-03-20
Hollrah, Glennon H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D30794
Patent
active
049103237
ABSTRACT:
2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and methods of preparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower alkyl, lower alkoxy, hydroxy and nitro. The substituents at the 2-position of the cyclohexane ring are --(CH.sub.2).sub.n NR.sup.1 R.sup.2 where n is 0, 1 or 2 and R.sup.1 and R.sup.2 are each independently hydrogen and alkyl of 1-3 carbons. These compounds are useful as antidepressants and analgesics.
Various other compounds which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.
REFERENCES:
patent: 4404221 (1983-09-01), Glamkowski et al.
patent: 4517311 (1985-05-01), Glamkowski et al.
patent: 4594435 (1986-06-01), Glamkowski et al.
patent: 4623657 (1986-11-01), Glamkowski et al.
Glamkowski Edward J.
Jones Michael C.
Hoechst Roussel Pharmaceuticals Inc.
Hollrah Glennon H.
Ikeda Tatsuya
Trinh Ba K.
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