2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and inter

Details 2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and inter 2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and inter

1983-03-02

1989-07-11

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564307, C07C 8728

Patent

active

048474142

ABSTRACT:
2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and methods of preparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower alkyl, lower alkoxy, hydroxy and nitro. The substituents at the 2-position of the cyclohexane ring are --(CH.sub.2).sub.n NR.sup.1 R.sup.2 where n is 0, 1 or 2 and R.sup.1 and R.sup.2 are each independently hydrogen and alkyl of 1-3 carbons. These compounds are useful as antidepressants and analgesics.
Various other compounds which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.

REFERENCES:
patent: 3470249 (1969-09-01), Frankus et al.
patent: 3652769 (1972-03-01), Saari
patent: 3974157 (1976-08-01), Shetty et al.
Casy et al., "Jorn. Chem. Soc. London", pp. 3635-3638 (1964).

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