2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their

Details 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their

1982-09-13

1985-05-14

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549345, 568705, A61K 3134, C07D30794

Patent

active

045173117

ABSTRACT:
2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and methods of praparing same are described. On the aromatic portion of the benzofuran ring, there may be a substituent or substituents including halogen, amino, lower-alkyl-substituted amino, lower alkyl, lower alkoxy, hydroxy and nitro. The substituents at the 2-position of the cycloalkane ring are --(CH.sub.2).sub.n NR.sup.1 R.sup.2 where n is 0, 1 or 2 and R.sup.1 and R.sup.2 are each independently hydrogen and alkyl of 1-3 carbons. These compounds are useful as antidepressants and analgesics.
Various other compounds which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.

REFERENCES:
patent: 3959475 (1976-05-01), Bauer et al.
patent: 4166119 (1979-08-01), Effland et al.
patent: 4166120 (1979-08-01), Effland et al.
patent: 4263317 (1981-04-01), Martin et al.
patent: 4404221 (1983-09-01), Glamkowski et al.

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