Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-10-28
1994-04-19
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514314, 514255, 514256, 546172, 546174, 546175, 544336, 544242, C07D40306, C07D21548, A61K 3147, A61K 31505
Patent
active
053045637
ABSTRACT:
The title compounds are prepared either by reacting the corresponding halogenomethylquinolines with substituted phenols, optionally subsequently alkylating these or hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The new phenyl-substituted quinolines are utilizable as active substances in medicaments, in particular as lipoxygenase inhibitors.
REFERENCES:
patent: 4929626 (1990-05-01), Mohrs et al.
patent: 4970215 (1990-11-01), Mohrs et al.
patent: 5091392 (1992-02-01), Raddatz et al.
Henri Ulrich, "The Reaction of Sulfonylureas and Sulfonamides with Carbonyl Chloride. A New Synthesis of Isocynates," J. Org. Chem., 1966, pp. 2658-2661.
Gunter E. Jeromin, "Seitenkettenchlorierungen von N-Heterocyclen mit Trichlorisocyanursaure," in Chem. Bes., 120, 1987, pp. 649-651.
John C. Sheehan, "Total Synthesis of a Monocyclic Peptide Lactone Antibiotic, Etamycin," in Journal of the Am. Chem. Soc., 1973, pp. 875-879.
Gerd Utermann, "Genetic Variants of Group A Apolipoproteins," in The Journal of Biological Chemistry, Jan. 10, 1982, pp. 501-507.
N. Leo Benoiton, "A Series of Lysyldipeptide Derivatives for Racemization Studies in Peptide Synthesis," in Int. J. Peptide Res., 1979, pp. 403-408.
N. Leon Benoiton, "Studies on Racemization During Couplings Using a Series of Model Tripeptides Involving Activates Residues with Unfunctionalized Side Chains," in J. Peptide Protein Res., 1981, pp. 197-204.
"Trimethylcyclohexande," in Beilstein's BANO V, pp. 43, 29, 15 and 109, (1922).
Pierre Borgeat, "Arachidonic acid metabolism in polymorphonuclear Leukocytes: Effects of ionophore A23187," in Prac. Natl. Acad. Sci. USA, May 1979, pp. 2148-2152.
Fruchtmann Romanis
Hatzelmann Armin
Kohlsdorfer Christian
Matzke Michael
Mohrs Klaus-Helmut
Bayer Aktiengesellschaft
Springer David B.
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