2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones

Details 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones

1983-10-12

1985-12-24

Lesmes, George F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

514258, 544329, C07D48704, A61K 31505

Patent

active

045607532

ABSTRACT:
2-Q-6-Q'-8-R-pyrido[2,3-d]pyrimidin-5(8H)-ones (I), where Q is 4(or 3)-hydroxyphenyl, 4(or 3)-methoxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents, R' is hydrogen or alkyl having one to four carbon atoms, Q is hydrogen, amino or nitro, and R is alkyl having from one to four carbon atoms, CH(C.sub.2 H.sub.5).sub.2, (CH.sub.2).sub.n .dbd.CHCH.sub.2 where n is 1 or 2, or Y--Z where Y is alkylene having from two to four carbon atoms and having its connecting linkages on different carbon atoms and Z is hydroxy, OR.sub.1 or NR.sub.1 R.sub.2 where R.sub.1 and R.sub.2 are each methyl or ethyl, or acid-addition salts thereof, and their preparation are shown. Also shown is the cardiotonic use of I where Q is 4(or 3)-hydroxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents and Q' is hydrogen or amino.

REFERENCES:
patent: 3642797 (1972-02-01), Lesher
patent: 3873545 (1975-03-01), Osselaere et al.
patent: 3992380 (1976-11-01), Lesher et al.
patent: 4018770 (1977-04-01), Lesher et al.
patent: 4380632 (1983-04-01), Steffen
patent: 4432981 (1984-02-01), Lesher et al.
Matsumoto et al, [Japanese Kokai 78 18,600, published Feb. 20, 1978; C.A., 89, 24,351d (1978)].

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