2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10)...

Details 2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10)... 2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10)...

2005-11-22

2005-11-22

Badio, Barbara P. (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C552S541000, C552S548000, C552S553000, C552S555000

Reexamination Certificate

active

06967195

ABSTRACT:
Compounds of formula (I) in which: R1represents a hydrogen atom or an O-protecting group; R2represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R3represents a methyl group having α- or β-configuration; X represents a C1-3alkylene group or a valence bond; Y represents a carboxaldehyde group or a group of formula —C(R4)(R5)OR1where R1is as defined above and R4and R5, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of R4and R5does not exceed three atoms, with the proviso that X is a valence bond when both R4and R5are other than hydrogen; and the dotted line signifies that a double bond may optionally be present at the 16(17)-position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.

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