2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines

Details 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines 2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines

1974-09-17

1976-02-24

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, C07D21336

Patent

active

039404048

ABSTRACT:
A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein disclosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.

REFERENCES:
patent: 3764604 (1973-10-01), Ash et al.
La Montagne J. of Medicinal Chemistry, Vol. 16, No. 1, (1973), pp. 68-72.
Markovac et al., J. of Medicinal Chemistry, Vol. 15, No. 9, (1972), pp. 918-922.

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