2-[(substituted)-phenoxymethyl]quinolines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514312, 514313, 546152, 546153, 546155, 546156, 546159, A61K 3147, C07D21514

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active

046614990

ABSTRACT:
Compounds having the formula: ##STR1## are selective antagonists of leukotrienes of D.sub.4 and inhibitors of the syntheses of LTA.sub.4, B.sub.4, C.sub.4, D.sub.4, E.sub.4, and F.sub.4. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, and cytoprotective agents.

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J. Chem. Soc. Dalton 1259, 1264 (1980), Antony Deeming et al.
Org. Reactions, VII, R. Adams, ed., p. 82, (1953).
Aldrich Fine Chemicals, 58, 145 (1986).
Reagents for Org. Syn., 4, Fieser & Fieser, 448-449 (1974).

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