Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-05-27
1990-07-17
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544139, 544146, 544152, 544370, 544379, 546210, 546212, 546214, 546231, 548342, 549 68, 549 76, 549474, 549493, 552299, A61K 31445
Patent
active
049421700
ABSTRACT:
The present invention relates to the treatment of diseases caused by invading organisms in a host by first identifying an enzymatic difference between the host and the invading organism and then administering to the host a pharmaceutically effective amount of a subversive substrate for the differing enzyme of the invading organism, whereby the action of the differing enzyme causes a result counter to the intended result and function of the enzyme that results in its debilitation or death. In particular, treatment of parasitic diseases caused by kinetoplastids including trypanosomes and leishmanias, e.g., African sleeping sickness, Chagas' disease, oriental sore and kala-azar is accomplished by administration of a pharmaceutically effective antiparasitic amount of a competitive toxigenic substrate for trypanothione reductase. Methods of treatment and compositions therefor contain a competitive toxigenic substrate for trypanothione reductase. Numerous compounds and corresponding compositions are disclosed.
REFERENCES:
patent: 2663710 (1953-12-01), Hayes
patent: 2726241 (1955-12-01), Gever et al.
patent: 3127420 (1964-03-01), Ebetino
Cerami Anthony
Henderson Graeme B.
Ulrich Peter C.
Hollrah Glennon H.
The Rockefeller University
Turnipseed James H.
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