Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-12-13
1995-08-29
Rizzo, Nicholas
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514202, 514204, 514205, 540221, 540222, 540225, 540226, C07D50120, A61K 31545
Patent
active
054460379
ABSTRACT:
This invention relates to 2-[(substituted)methylene]cephalosporin sulfones and in particular 2-[(heteroaryl substituted)methylene]cephalosporin sulfones which are effective elastase inhibitors as well as effective thrombin inhibitors and therefore are useful as anti-inflammatory, anti-degenerative and anti-thrombin agents.
REFERENCES:
patent: 4547371 (1985-10-01), Doherty et al.
patent: 5077286 (1991-12-01), Bissolino et al.
patent: 5348952 (1994-09-01), Bissolino et al.
patent: 5356888 (1994-10-01), Alpegiani et al.
Alpagiani et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 9, pp. 1127-1132, 1992.
Atwal Harninder
Czajkowski David
Fiakpui Charles
Maiti Samarendra
Micetich Ronald G.
Rizzo Nicholas
SynPhar Laboratories, Inc.
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