2-Substituted-indole-1-lower-alkanecarboxamides

Details 2-Substituted-indole-1-lower-alkanecarboxamides 2-Substituted-indole-1-lower-alkanecarboxamides

1975-10-21

1977-05-03

Brust, Joseph P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032613R, 26032613D, 424274, C07D20904, C07D20908, C07D20912

Patent

active

040214486

ABSTRACT:
2-Substituted-indole-1-lower-alkanecarboxamides, prepared by amidation of the corresponding acid or ester; by hydrolysis or thiohydrolysis of the corresponding carbonitrile; by alkylation of a suitable indole with a halo-lower-alkanecarboxamide; or by hydrolysis of a 1-indolechlorosulfonylcarbamyl derivative, have anti-secretory and anti-ulcer activities.

REFERENCES:
patent: 3843683 (1974-10-01), Bell
patent: 3890348 (1975-06-01), Kathawala
Yamamoto et al., "Chem. Abstracts", vol. 78, No. 43265t (1973).
Swaminathan et al., "J. Org. Chem.", vol. 22, pp. 70-72 (1957).

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