2-substituted indane-2-mercaptoacetylamide disulfide derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

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540522, 514214, A61K 3133, C07D22310

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active

055678149

ABSTRACT:
The present invention relates to certain novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and of ACE.

REFERENCES:
patent: 3334091 (1967-07-01), Houlihan
patent: 3334095 (1967-08-01), Houluhan
patent: 4080449 (1978-03-01), Croisier et al.
patent: 4320057 (1982-03-01), Freed et al.
patent: 4391752 (1983-07-01), Crossley
patent: 4399136 (1983-08-01), Hassall et al.
patent: 4415496 (1983-11-01), Harris et al.
patent: 4487929 (1984-12-01), Hassall et al.
patent: 4512924 (1985-04-01), Attwoood et al.
patent: 4584294 (1986-04-01), Ruyle
patent: 4658024 (1987-04-01), Attwood et al.
patent: 4692438 (1987-09-01), Hassall et al.
patent: 4716232 (1987-12-01), Ternansky
patent: 4734504 (1988-03-01), Holmes
patent: 4734505 (1988-03-01), Holmes
patent: 4762924 (1988-08-01), Hassall et al.
patent: 4772701 (1988-09-01), Attwood et al.
patent: 4782149 (1988-11-01), Lawton et al.
patent: 4785093 (1988-11-01), Hassall et al.
patent: 4808713 (1989-02-01), Attwood et al.
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4826980 (1989-05-01), Hassall et al.
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5238932 (1993-08-01), Flynn et al.
Flynn, et al., J. Am. Chem. Soc. 109, 7914 (1987).
Flynn, et al., Peptide Chemistry (1987); T. Shiba & Sakakibara (ed.), Protein Research Foundation, Osaka (1988).
Flynn, et al., Tetrahedron Letters, vol. 31 (6), 815-88 (1990).
Attwood, et al., J. Chem. Soc. Perkin Trans. I, pp. 1011-1019 (1986).
Natoff, et al., Drugs of the Future, vol. 12 (5): 475-483 (1987).
Powell Jerry S. et al., Journal of American College of Cardiology, vol. 17, No. 6, pp. 137B-142B (May 1991).
Davis, Harry R. et al., Supplement I Circulation, vol. 86, No. 4 p. I-220(0873), (Oct. 1992).
W. H. Parsons et al. Biochemical and Biophysical Research Communications, vol. 117, No. 1, 1993 (Nov. 30, 1983).
Burkholder, et al. Bioorganic and Medical Chem. Letters, vol. 3, No. 2, pp. 231-234, 1993.
Flynn et al., J. Med. Chem.1993, 36 2420-2423.
J. Med. Chem. 1992, 35, 823-832, Timothy D. Ocain et al.
Bioorganic and Medical Chem. Letters, vol. 1, 309, 1991.
Fournie-Zaluski, Marie-Claude et al., J. Med. Chem., 1992 vol. 35, pp. 2473-2481.
Fournie-Zaluski, Marie-Claude et al., J. Med. Chem., 1992 vol. 35, pp. 1259-1266.
French, John F., Jour. of Pharm and Exper. Therapeutics, vol. 268, No. 1, pp. 180-18.6 (1994).

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