2-substituted imidazoquinoxaline diones, a new class of GABA bra

Details 2-substituted imidazoquinoxaline diones, a new class of GABA bra 2-substituted imidazoquinoxaline diones, a new class of GABA bra

1990-10-31

1992-07-14

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544 80, 544115, 546278, 546306, 549480, 564 45, 564 50, C07D48704, C07D40104, C07D23372, A61K 31495

Patent

active

051304309

ABSTRACT:
The invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent organic or inorganic substituents; X represents hydrogen, halogen, hydroxy or amino and W represents phenyl, thienyl or pyridyl, each of which may be unsubstituted or mono or disubstituted with organic or inorganic substituents.
These compounds are highly selective agonists, antagonists or inverse agonists for GABA a brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

REFERENCES:
patent: 4312870 (1982-01-01), Yokoyama
patent: 4440929 (1984-04-01), Lee
patent: 4713383 (1987-12-01), Francis

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