2-substituted imidazo[1,2-c]pyrimidines having anxiolytic proper

Details 2-substituted imidazo[1,2-c]pyrimidines having anxiolytic proper 2-substituted imidazo[1,2-c]pyrimidines having anxiolytic proper

1984-12-14

1987-02-17

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544281, A61K 31505, C07D47102

Patent

active

046439994

ABSTRACT:
Novel imidazo[1,2-c]pyrimidines of the formula ##STR1## wherein R is an aryl of 6 to 12 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen and alkyl, alkoxy and alkylthio of 1 to 5 carbon atoms when R.sub.2 and R.sub.3 together form a carbon-nitrogen bond or R.sub.1 and R.sub.2 together are .dbd.0 when R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms, R.sub.4 is selected from the group consisting of alkoxy and alkylthio of 1 to 5 carbon atoms, R.sub.5 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anxiolytic properties.

REFERENCES:
patent: 4223031 (1980-09-01), Covington et al.
patent: 4353903 (1982-10-01), Fabiani et al.
patent: 4521422 (1985-06-01), Dusza et al.
patent: 4532243 (1985-07-01), Tully

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