2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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Details

C552S531000, C552S610000, C552S614000, C552S626000

Reexamination Certificate

active

10546030

ABSTRACT:
Disclosed are compounds of formula Iand use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization.

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patent: WO 98/42729 (1998-10-01), None
patent: WO 99/33858 (1999-07-01), None
patent: WO 0118028 (2001-03-01), None
MacCarthy-Morrogh L. et al: “Differential Effects of Estrone and Estrone-3-O-Sulfamate Derivatives on Mitotic Arrest, Apoptosis, and Microtubule Assembly in Human Breast Cancer Cells” Cancer Research, vol. 60, pp. 5441-5450, 2000.
Purohit A. et al: “Recent advances in the development of steroid sulphatase inhibitors” Journal of Steroid Biochemistry and Molecular Biology, Elsevier Science Ltd., vol. 69, (1999), pp. 227-238.
Singh A. et al.: “Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate” Molecular and Cellular Endocrinology, vol. 160 (2000), pp. 61-66.

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