2-substituted ergolines useful as neuroleptics and antidepressan

Details 2-substituted ergolines useful as neuroleptics and antidepressan 2-substituted ergolines useful as neuroleptics and antidepressan

1985-04-09

1988-03-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 14, 546 67, 546 68, 546 69, A61K 3148, C07F 702, C07D45704

Patent

active

047313676

ABSTRACT:
Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C.sub.8 -C.sub.9 and C.sub.9 -C.sub.10 each independently is a CC-single or a C.dbd.C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the .alpha.- or .beta.-configuration where C.sub.8 -C.sub.9 is a CC-single bond,

REFERENCES:
patent: 3029243 (1962-04-01), Olin
patent: 3251846 (1966-05-01), Semonsky et al.
patent: 3953454 (1976-04-01), Zikan et al.
patent: 4382940 (1983-05-01), Bernardi et al.
patent: 4500712 (1985-02-01), Bernardi et al.
Berde, et al., Ergot Alkaloids and Related Compounds, Springer-Verlag, New York (1978), pp. 74, 469-470.
Pratt, et al., "Organosilicon Compounds, XX . . . ", J. Org. Chem., vol. 40, (1975), pp. 1090-1093.

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