2-substituted ergolines having neuroleptic and antidepressant ac

Details 2-substituted ergolines having neuroleptic and antidepressant ac 2-substituted ergolines having neuroleptic and antidepressant ac

1987-12-22

1989-07-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, 546 68, A61K 3148, C07D45712

Patent

active

048472620

ABSTRACT:
Novel ergoline derivatives, substituted in the 2-position, of the formula ##STR1## wherein C.sub.8 ---C.sub.9 and C.sub.9 ---C.sub.10 each independently is a CC-single or a C.dbd.C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the .alpha.- or .beta.-configuration where C.sub.8 ---C.sub.9 is a CC-single bond,

REFERENCES:
patent: 3029243 (1962-04-01), Olin
patent: 3251846 (1966-05-01), Semonsky
patent: 3953454 (1976-04-01), Zikan et al.
patent: 4382940 (1983-05-01), Bernardi et al.
patent: 4500712 (1985-02-01), Bernardi et al.
patent: 4731367 (1988-03-01), Sauer et al.
Berde et al., Ergot Alkaloids and Related Compounds, (1978), pp. 74, 469-470.
Pratt et al., J. Org. Chem., vol. 40, (1975), pp. 1090-1093.

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